During NASA’s SpaceX Crew-13 mission aboard the International Space Station, astronauts will support a series of biomedical and human performance investigations, including a new collaborative effort to study how spaceflight affects blood flow and clotting. NASA also is testing crew members’ manual piloting skills, evaluating methods to counter vision and brain changes, gathering essential health data to inform future missions, and measuring forces astronauts experience during their return to Earth to help refine re-entry hardware and procedures.